Mercury (Hg2+) suppression of potassium currents of outer hair cells
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چکیده
منابع مشابه
Mercury (Hg2+) suppression of potassium currents of outer hair cells.
The heavy metal mercury (Hg(2+)) is an insidious environmental pollutant that causes toxic effects on sensory systems. It is well known that the group IIB divalent cation Hg(2+) is an inhibitor of the group I monovalent potassium (K(+)) cation pore-forming channel in several biological preparations. Here, we used the whole cell patch clamp technique on freshly isolated outer hair cells (OHCs) o...
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To study the functional expression of KCNQ gene in outer hair cells (OHCs) and Deiters' cells, the effects of linopirdine on the whole cell K(+) current were investigated by using the whole cell variant of patch clamp technique in the present study. The outward tetraethylammonium (TEA)-sensitive K(+) current and the inward K(+) current (I(Kn)) in OHCs were recorded and measured before and after...
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The effects of fluoxetine (Prozac), a widely used antidepressant drug, on K+ channel in outer hair cells isolated from guinea pig cochlea were studied using the whole-cell patch clamp technique. Fluoxetine potently inhibited leak K+ currents with an IC50 of 0.78 microM. The inhibition was reversible and voltage-independent. At 45- to 103-fold higher concentrations than the plasma levels, fluoxe...
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Van Den Abbeele, Thierry, Jacques Teulon, and Patrice Tran Ba Huy. Two types of voltage-dependent potassium channels in outer hair cells from the guinea pig cochlea. Am. J. Physiol. 277 (Cell Physiol. 46): C913–C925, 1999.— Cell-attached and cell-free configurations of the patch-clamp technique were used to investigate the conductive properties and regulation of the major K1 channels in the bas...
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ژورنال
عنوان ژورنال: Neurotoxicology and Teratology
سال: 2003
ISSN: 0892-0362
DOI: 10.1016/s0892-0362(03)00008-4